In groups given higher doses of cobra venom (2 to 5 times the lethal dose) all mice succumbed, but those treated with a single dose of neostigmine survived significantly longer than the controls. 10 of 15 mice given the lowest dose of venom, followed by the treatment within 10 minutes, survived and later exhibited completely normal behavior, while 100 percent of control mice died. The results of this pilot study were recently published in the Journal of Tropical Medicine.ĭuring the course of the experiment, separate groups of mice were given varying doses of venom (all above lethal limits) and then treated with the antiparalytic treatment at two different time intervals: within 1-2 minutes after envenomation and 10 minutes after envenomation. These findings support the team's idea that providing fast, accessible, and easy-to-administer treatment can increase survival rates in victims of venomous snakebite. Mice injected with otherwise fatal doses of venom outlived and in many cases survived after being treated with the antiparalytic agent, neostigmine. Last summer, the team tested the effectiveness of a nasally administered antiparalytic drug on mice injected with high doses of Indian cobra ( Naja naja) venom. Samuel of Trinity College Dublin, Ireland has taken another promising step toward developing a universal antidote for snakebite. Matthew Lewin of the California Academy of Sciences and Dr. SAN FRANCISCO (May 28, 2014)-A team of researchers, led by Dr.
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